2024 Pdgfra-creert2

Pdgfra-creert2

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Splet11. apr. 2024 · Liver sinusoidal endothelial cells play pivotal roles in liver function and influences the development of liver fibrosis. This study revealed the molecular mechanism by which liver sinusoidal endothe... Splet19. mar. 2024 · Pdgfra-CreERT2 mice were a kind gift from Bill Richardson (University College London, London, UK). Fra-2 Tg mice were kindly provided by Erwin Wagner …

Generation and characterization of PDGFRα-GFPCreERT2 knock-In …

Splet06. apr. 2024 · (A) Whole-mount images of SI from Pdgfra CreERT2;R26R mT/mG mice, where Cre-expressing cells convert ubiquitous tdTom fluorescence (red) to eGFP signal (green), counterstained for F-actin (phalloidin, white). 30 μm z stack overlay. The dashed box is enlarged to the right and the crypt in that image is marked with a dashed white line. Splet14. sep. 2016 · In the central nervous system (CNS) platelet derived growth factor receptor alpha (PDGFRα) is expressed exclusively by oligodendrocyte progenitor cells (OPCs), … norm mineta and alan simpson

Tg(Pdgfra-cre/ERT2)1Wdr Transgene Detail MGI Mouse …

SpletThe data suggest that Pdgfrα-CreERT2 transgenic mice can be used to achieve robust recombination in OPCs, while having a minimal effect on most PDGFRα+ cell populations outside of the CNS. In the central nervous system (CNS) platelet derived growth factor receptor alpha (PDGFRα) is expressed exclusively by oligodendrocyte progenitor cells … Splet关于我们杰克森实验室（jax）是一家独立的非盈利性生物医学研究机构，拥有超过3,000名员工。其总部位于缅因州巴港，并在此设立了一家由美国国家癌症中心指定的癌症研究中心。 SpletA transgenic mouse line, Pdgfra-CreERT2, allowed temporally-controlled, permanent activation of YFP expression in PDGFRa-expressing OLPs and their differentiated progeny in the Rosa26-YFP reporter background. In vivo BrdU labelling and fate mapping of YFP-positive cells revealed that, in the corpus callosum, approximately half of the OLPs were ... norm moody manchester nh

PDGFRα plays a crucial role in connective tissue remodeling - Nature

Consequences of PDGFRα+ fibroblast reduction in adult murine …

SpletFig1. Cre-mediated recombination in the large and small intestine of Pdgfra Cre/+; Rosa26 tdTomato/+ mouse.. Fig2. Cre-mediated recombination in the retina of Pdgfra Cre/+; … SpletPDGFRA, i.e. platelet-derived growth factor receptor A, also termed PDGFRα, i.e. platelet-derived growth factor receptor α, or CD140a i.e. Cluster of Differentiation 140a, is a … how to remove watermark in istockSpletWe recently received heterozygous C57BL/6 Ubiad1 lox/lox mice that were are crossing to homozygosity and then with endothelial specific Cre driver lines such as cdh5:CreERT2 and pdgf:CreERT2. Task 4) is based to address the function of the mevalonate pathway in developmental angiogenesis and in current anti-angiogenic therapies. how to remove watermark in obs

"Splet22. mar. 2024 · Postnatal deletion of the Igf1r gene impairs alveolarization. Constitutive deletion of the mouse Igf1r gene caused respiratory failure following birth ().Since the deletion of Igf1r with an epithelial-specific Nkx2-1-Cre did not alter lung morphogenesis (), we tested whether its conditional deletion in lung fibroblasts influenced postnatal lung … " - Pdgfra-creert2

Pdgfra-creert2

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SpletPericytes are essential mural cells distinguished by their association with small caliber blood vessels and the presence of a basement membrane shared with endothelial cells. … Splet07. dec. 2015 · In the present study, the Pdgfra gene was systemically inactivated in adult mouse (α-KO mouse) and the role of PDGFRα was examined in the subcutaneously …

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SpletStrain #: 018280. RRID:IMSR_JAX:018280. Pdgfra-creERTM transgenic mice can be used to create conditional mutations in oligodendrocyte precursor or NG2 + cells in the adult …

Splet15. mar. 2024 · Fosl2tg; Pdgfra-CreERT2; tdTomatoﬂox, Fosl2tg; Acta2-CreERT2; tdTomatoﬂox, and littermate controls were eutha-nized, and lungs harvested at 20 wk of … Splet01. okt. 2024 · 1 Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.. 2 Selzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.. 3 Department of Vascular Surgery, DeBakey Heart and Vascular …

Splet06. apr. 2024 · (A) Whole-mount images of SI from Pdgfra CreERT2;R26R mT/mG mice, where Cre-expressing cells convert ubiquitous tdTom fluorescence (red) to eGFP signal (green), counterstained for F-actin (phalloidin, white). 30 μm z stack overlay. The dashed box is enlarged to the right and the crypt in that image is marked with a dashed white line. Splet17. maj 2024 · The tamoxifen-responsive conditional Cdh5-CreERT2 is commonly used for endothelial cell specific conditional deletion of loxP-flanked gene sequences. To address the role of endothelial cell Shb gene for B16F10 melanoma immune responses, tamoxifen-injected Cdh5-CreERT2/WT and Cdh5-CreERT2/Shb flo …

SpletMoreover, lineage tracing experiments using transgenic mice that express Cre recombinase in the OPCs (NG2-Cre and PDGFRA-CreERT2) revealed that OPCs produce oligodendrocytes in the gray and white matter, but not astrocytes in the neocortex, although some astrocytes were produced in the ventral forebrain (Zhu et al., 2007, 2012; Rivers et al ...

Splet032770 B6.129S- Pdgfra tm1.1(cre/ERT2)Blh /J Pdgfrα-CreER T2 mice have a cre/ERT2 fusion gene inserted into the start codon of the platelet derived growth factor receptor, … norm nbn s 21-204-2:2020SpletFig1. Cre-mediated recombination in the large and small intestine of Pdgfra Cre/+; Rosa26 tdTomato/+ mouse.. Fig2. Cre-mediated recombination in the retina of Pdgfra Cre/+; Rosa26 tdTomato/+ mouse.. Fig3. Detection of tdTomato(red) in various tissues of Pdgfra Cre/+; Rosa26 tdTomato/+ mice. Tdtomato can be detected in the brain, retina, pituitary gland, … how to remove watermark in manycamSpletTo investigate the role of macroautophagy/autophagy in AT fibrogenesis, we used Pdgfra-CreErt2 transgenic mice to create conditional deletion of Atg7 alleles in AT progenitor cells (atg7 cKO) and examined sex-dependent, depot-specific AT remodeling in high-fat diet (HFD)-fed mice. normoblasts definitionSplet07. mar. 2024 · Mutation details : The mouse Pdgfb promoter was used to drive inducible expression of an improved cre gene fused to ERT2 and followed by an IRES-EGFP then an … how to remove watermark in paintSpletSham and overloaded mesenchymal progenitors from Control (Pdgfra-CreERT2) or cdKO (Pdgfra-CreERT2::Yap1 flox/flox ::Taz flox/flox) were used for RNA-seq analysis. Contributor(s) Kaneshige A, Kaji T, Yasuyuki O, Fukada S: Citation(s) 34856120: Submission date: Dec 08, 2024: Last update date: Feb 18, 2024: how to remove watermark in pixiesetSpletMutation details: A mouse PAC clone (RPCI21-546M3) containing the Pdgfra gene was modified by the insertion of a tamoxifen-inducible cre recombinase gene into exon 2 … how to remove watermark in powerdirector 365Splet24. maj 2016 · By conditionally knocking out the transcription factor Myelin regulatory factor (Myrf) in OPs, using a tamoxifen-inducible Pdgfra-CreERT2 transgene, we were able to show that blocking production of new oligodendrocytes post-tamoxifen impaired the animals’ ability to learn a motor skill (running on wheels with unevenly spaced rungs), … how to remove watermark in pdf xchange editor