Fbw7 motif
WebJan 8, 2024 · For each motif represented, percentage of target and background sequences with the motif and p-value are shown. ( G ) Relationship between protein-coding genes that are co-bound by promoter-proximal MYC and HCF-1 N by ChIP-Seq, and are significantly (false discovery rate [FDR] < 0.05) decreased or increased in response to the 4A or … WebSep 3, 2024 · Furthermore, the phosphorylation of Brg1 Ser31/Ser35 sites, within the FBW7 degron consensus motif, enhanced the interaction between Brg1 and FBW7 and thus accelerated the ubiquitination of Brg1 ...
Fbw7 motif
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WebTarget Information: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. WebApr 9, 2013 · Consistently, Fbw7-deficient embryos die in utero around embryonic day 10.5 (E10.5) with remarkable abnormalities in vascular development, indicating that FBW7 is a physiological regulator of ...
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either diff… WebMar 3, 2024 · Background The tumor suppressor FBW7 is the substrate recognition component of the SCF E3-ubiquitin ligase complex that mediates proteolytic degradation of various oncogenic proteins. However, the role of FBW7 in ovarian cancer progression remains inadequately understood. Methods IP-MASS, co-IP, immunohistochemistry, and …
WebMoreover, knockdown of CK2α, Csn5, or Fbw7 reversed HDAC inhibitor-induced topoIIα degradation. Mutational analysis indicates that the 1361SPKLSNKE1368 motif plays a crucial role in regulating topoIIα protein stability. This motif contains the consensus recognition sites for CK2 (SXXE), glycogen synthase kinase (GSK)3β (SXXXS), and … WebFeb 1, 2024 · AbstractGlycogen synthase kinase 3β (GSK3β), an ubiquitously expressed serine/threonine kinase is reported to be overexpressed and hyperactivated in cancers including acute myeloid leukemia (AML) where it promotes self-renewal, growth, and survival of AML cells. Therefore, GSK3β inhibition results in AML cell growth inhibition …
WebF-box and WD repeat domain-containing 7 (FBW7), the substrate-binding subunit of E3 ubiquitin ligase SCF(FBW7) (a complex of SKP1, cullin-1 and FBW7), plays important roles in various physiological and pathological processes. Although FBW7 is required for vascular development, its function in the en …
WebAug 1, 2014 · Most Fbw7 substrates contain a phosphodegron motif that serves as the recognition motif for Fbw7 interaction (Welcker and Clurman, 2008). Multiple higher molecular weight bands of Ngn3-HA detected by immunoblot collapsed after calf intestinal phosphatase (CIP) treatment, suggesting that they represent phosphorylated forms. re2 googleWebmotif called the CDC4 phosphodegron (CPD) in its substrates (24, 29, 34). Numerous cancer-associated mutations of Fbw7 havebeenfoundinvariouscancers(35),andlossofFbw7func-tion results in tumorigenesis (36, 37). However, the mecha-*This work was supported in part by Grant 06DZ22923 from … re1 remake modWebFBW7 was also immunoprecipitated by a previous lot (A301-720A-1) of this antibody. For blotting immunoprecipitated FBW7, A301-720A was used at 1 µg/ml ... is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ... re1 remake modsWebJul 31, 2012 · The 1–665 mutant lacks a highly conserved Fbw7 degron motif at amino acid 705–711. Accordingly, no interaction between Fbw7 and the 1–445 deletion, … re1 remake mo diskWebFeb 18, 2024 · The levels of FIR family (FIR, FIRΔexon2 and PUF60), BRG1, Snai1, FBW7, E-cadherin, c-Myc, cyclin-E, ... (WD)-like motif in the degron pocket of FBW7 as a UHM-ligand motif. Together, FIRΔexon2 engages in multi-step post-transcriptional regulation of BRG1, affecting EMT through the BRG1/Snai1/E-cadherin pathway and promoting tumor ... re1 remake painting puzzleWebFBP then binds to Skp1 of the SCF complex using an F-box motif, bringing the target protein into proximity with the functional E2 ubiquitin-conjugating enzyme. FBP is also essential in regulating SCF activity during the course of the cell cycle. ... Fbw7, which is the human homolog of cdc4 in yeast, is an FBP that targets Cyclin E, Myc, Notch ... re2goWebJan 8, 2024 · A conserved motif of pT/pSPXXpS/pT/D/E in substrates' CPD is a pre-requisite for FBW7-targeted binding and subsequent degradation [8]. In current study, … duo jenifer slimane