WebHuman cytomegalovirus (CMV) infection continues to be one of the most important and life threatening complications after allogeneic stem cell transplantation (SCT).. The reconstitution of CMV-specific T cell responses after SCT has been demonstrated to be protective against the development of CMV disease.. To improve T cell immunity … WebJun 30, 2015 · To the best of our knowledge, this is the first effort to evaluate the clinical utility of the commercial CMV ELISPOT assay in transplant recipients. It is noteworthy that the pp65-specific but not the IE1-specific T cell response was associated with the development of CMV after SOT. Both pp65 and IE-1 are considered dominant T cell …
History of Changes for Study: NCT03924219 - clinicaltrials.gov
WebJun 1, 2002 · Cell-mediated immunity represents an essential host factor in the control of persistent infection and the recovery from CMV disease.6-10 An increased understanding of the mechanisms by which T cells recognize virus and tumor-specific antigens has stimulated much interest in the use of specific T cells as adoptive immunotherapy for … WebRecently, assays for measurement of an individual patient's CMV immunity have been developed and are clinically available. One of these is the Viracor CMV T cell Immunity Panel. This flow cytometry based assay is performed on peripheral blood and measures cytokine release in response to CMV antigen stimulation by flow cytometry. other term of innovative
Peptide Processing Is Critical for T-Cell Memory Inflation and
WebOct 11, 2013 · The reconstitution of anti-viral cellular immunity following hematopoietic stem cell transplantation (HSCT) is crucial in preventing cytomegalovirus (CMV)-associated complications. Thus immunological … WebKeywords: T cell biology; clinical research/practice; infection and infectious agents-viral: Cytomegalovirus (CMV); infectious disease. Publication types Letter WebCMV pp65-specific T-cell responses were stronger following preemptive therapy than with antiviral prophylaxis in both CD4+ (A) ... Only patients who had samples available for both the nAb and T-cell assays were included in analyses of CMV immunity. Further details for both assays appear in eMethods in Supplement 2; ... rockingham mopar show