Blimp1 glycosylation
WebOct 30, 2024 · In mammals, Blimp1 (B lymphocyte-induced maturation protein 1) encoded by the prdm1 gene and its homolog Hobit (homolog of Blimp1 in T cells) encoded by znf683, represent key transcriptional … WebJun 2, 2024 · Glycosylation is an important posttranslational modification that covalently …
Blimp1 glycosylation
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WebFeb 21, 2006 · Biallelic inactivation of BLIMP1 by rearrangement and deletion in the Ly3 cell line. (A) BLIMP1 genomic locus: filled and empty boxes represent coding and noncoding exons, respectively. Arrows correspond to alternative transcription initiation sites, and triangles below the map depict the primers used for mutational analysis. WebApr 15, 2009 · Blimp1 associates with a multitude of chromatin modifying enzymes inducing epigenetic changes at specific targets to regulate these diverse cell fates. In this review, we focus on the novel and emerging roles of Blimp1 in multiple tissues, on mechanisms of transcriptional repression by Blimp1 and on the activity of Blimp1 as a tumor suppressor.
WebPRDM1/BLIMP-1 is a master transcription factor regulating downstream cytokines. It is activated by TLRs and IRF-4, and is crucial in T cell, B cell, and myeloid lineage cell differentiations. As a potent repressor of beta-interferon (IFN-β), BLIMP-1 competes for interferon regulatory factors (IRF) binding sites in the IFN-β promoter due to ... WebDec 22, 2024 · University of Alabama at Birmingham researcher Jianmei Leavenworth, M.D., Ph.D., has now identified the transcription factor Blimp1 as a new critical regulator of tumor-infiltrating T-reg cells ...
WebSep 1, 2024 · Overexpression of transcription factor BLIMP1/prdm1 leads to growth inhibition and enhanced secretory capacity in Chinese hamster ovary cells. Author links open overlay panel Mauro Torres a b, ... and for generating the complex processing requirements (e.g., folding, glycosylation and/or phosphorylation) needed for specific … WebOct 12, 2024 · Plasma cells also require a high rate of glucose uptake for glycolysis and …
WebFeb 10, 2011 · Blimp1 (also known as Prdm1) is a pleiotropic transcription factor that plays crucial roles in the differentiation of plasma cells and CD8 + effector T cells. 21-25 In both processes, Blimp1 is required for terminal differentiation and Blimp1 deficiency leads to loss of functional antibody-secreting cells and short-lived cytotoxic T cells. Moreover, in …
WebFlow Cytometry: BLIMP1/PRDM1 Antibody (3H2-E8) - BSA Free [NB600-235] - An … buy chiswell furnitureWebOct 15, 2012 · Stress in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), a signaling mechanism that allows cellular adaptation to ER stress by engaging pro-adaptive transcription factors and alleviating protein folding demand. One such transcription factor, X-box binding protein (XBP1), originates from the inositol-requiring … cell phone charms kawaiiWebMW performed most experiments, TP performed the flow-cytometric analyses of unimmunized PCs, the intracellular staining of IgM expression and the Blimp1 rescue experiments, PB performed the Xbp1 ChIP-seq experiment, AH and JS performed the glycosylation analysis, DK-P generated the Xbp1 Bio/+ mouse, SK generated the … buy chitsWebSep 28, 2012 · Primordial germ cells (PGCs) sequentially induce specific genes required for their development. We focused on epigenetic changes that regulate PGC-specific gene expression. mil-1, Blimp1, and Stella are preferentially expressed in PGCs, and their expression is upregulated during PGC differentiation. Here, we first determined DNA … cell phone charm rubber animeWebAbstract. The gene encoding the human BLIMP1, prdm1, is located on chromosome … cell phone charms kdramahttp://www.globalauthorid.com/WebPortal/AuthorView?wd=GAID10160321&rc=6A62E4 buy chitlins near meWebSep 1, 2002 · BLIMP1, BCL6 and B-cell fate. The differentiation of mature B cells into antibody-secreting plasma cells is controlled by the presence or absence of transcription factors, including B-lymphocyte ... cell phone charms windows phone